DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...
Scientists have uncovered how DnaA, the master key to DNA replication, opens the door to bacterial growth. This breakthroughpaves the way for new antibiotics to combat the rising tide of antibiotic ...
"If it ain't broke, don't fix it," goes the old adage, which Rice University professor James Chappell completely ignored in a ...
The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...
Initiation of DNA synthesis: a general model from studies with prokaryotes -- Escherichia coli oriC -- Lambda phage origin: a familiar refrain -- Regulatory transcription factors and the initiation of ...
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