Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ ...
Aug 2, 2023 · Soluble epoxide hydrolase (sEH) is expressed in both peripheral tissues and CNS. Its upregulation has been implicated in multiple neurological conditions, including depression, …
Epoxide Hydrolase, a Fat New Target for Alzheimer’s Therapy?
Dec 15, 2020 · Given that epoxide hydrolase inhibitors are already being tested in the clinic for other conditions, they may have the potential to become a new class of AD drug. Darryl Zeldin, National …
Soluble epoxide hydrolase: a next-generation drug target for Alzheimer ...
Gregory A, Tang C, Fan F. Soluble epoxide hydrolase: a next-generation drug target for Alzheimer's disease and related dementias. Neural Regen Res. 2025 Sep 1;20 (9):2585-2586.
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse ...
Dec 15, 2020 · Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Sci Rep. 2018 Mar 27;8 (1):5279. PubMed. O'Brien CE, Santos PT, Kulikowicz E, Lee JK, …
Could Inhibiting a Liver Enzyme Ameliorate Alzheimer’s ... - ALZFORUM
Aug 2, 2023 · But what if targeting a peripheral enzyme could do the job? In the June 26 Neuron online, researchers led by Xin-Hong Zhu at Shenzhen University, China, reported that inhibiting a liver …
Genetic deletion of soluble epoxide hydrolase delays the progression …
Lee HT, Lee KI, Chen CH, Lee TS. Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer's disease. J Neuroinflammation. 2019 Dec 17;16 (1):267. PubMed.
C9orf72-associated neurodegeneration in ALS-FTD: breaking new …
Herrmann D, Parlato R. C9orf72-associated neurodegeneration in ALS-FTD: breaking new ground in ribosomal RNA and nucleolar dysfunction. Cell Tissue Res. 2018 Aug;373 (2):351-360. Epub 2018 …
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DNL919 - ALZFORUM
Background This TREM2 agonist antibody activates microglia to phagocytose amyloid. DNL919 contains a transferrin-receptor binding sequence engineered into its Fc domain. Thus, the antibody binds to …
New Therapeutic Strategy—Mimic the ApoE Christchurch Mutation?
Oct 24, 2023 · Further, a recent study showed that inhibition of liver enzyme soluble epoxide hydrolase drives a subsequent increase of 14,15-epoxyeicosatrienoic acid in the blood and into the brain, …